Heavy! Professor Zhao Gang, chairman of our special committee, jointly published an important article - "Principles and Progress of Cell Cryopreservation"
Release time:
2023-07-21
In recent years, low-temperature biomedicine, a less popular subject, is attracting more and more attention, attracting more and more scientists to join it. Among them, the cryopreservation technology of cells, tissues and organs, and even the entire human body continues to make progress and is gradually used in clinical applications.
Recently, Executive Director of the International Society of Cryobiology, Affiliated Professor of the University of Washington, Professor Zhao Gang of the University of Science and Technology of China, Zhou Xuexun of the Cryobiology Group of the Organized Biobank Branch of the Chinese Medical Biotechnology Association, and Professor Gao Dayong of the International Society of Cryobiology, President of the International Society of Cryobiology A joint article - "Principles and Progress of Cell Cryopreservation" was published online on the "Science China Life Sciences" website, sharing the progress of long-term cryopreservation technology of biological living cells. Among them, Professor Zhao Gang is the chairman of the Yinfeng Cryomedicine Expert Committee, and has provided tremendous academic support and technical guidance for Yinfeng’s cryopreservation and recovery research on tissues and organs.
The article points out that long-term cryopreservation of biological living cells is a key core technology to ensure the high-quality operation of modern biological sample banks. It is also the only available technology that can realize "pause" and "restart" of cell life and meet on-demand treatment. It has It has important basic research and clinical application value. Its standardization and large-scale application are playing an irreplaceable and important supporting role in many fields such as cell therapy, tissue engineering, regenerative medicine, reproductive medicine, clinical blood transfusion, drug development, animal genetic breeding and reproduction, etc. .
In contemporary cryopreservation systems, people are mainly committed to finding ideal cryoprotectants, and at the same time, under the established cryoprotectant solution system, multi-scale and all-round optimal control of the entire cryopreservation process is carried out. At present, Yinfeng Life Sciences Research Institute has screened and optimized a variety of cryoprotection ingredients with different properties, independently developed a more efficient cryoprotection solution and cooling program with lower cell damage, and combined extracorporeal circulation with six concentration gradient protection solutions. The perfusion connection and fusion provide a strong guarantee for maintaining the functional activity of tissue cells.
The article explains that after more than 70 years of efforts by international cryobiologists, the cryopreservation and recovery of most cells have been successfully achieved. For example, the preservation of reproductive cells such as sperm, eggs, and embryos has effectively alleviated the serious problem of reduced fertility around the world. The effects of different rewarming methods on cells that Zhao Gang's team is exploring provide a new research paradigm for cell cryopreservation. At the same time, the article mentioned that through more than 25 years of continuous original research, Gao Dayong's team has developed groundbreaking automated single-mode electromagnetic resonance (SMER) technology, which can efficiently convert electromagnetic energy into thermal energy and achieve rapid Uniform 3D heating to prevent fatal water molecule heavy ice crystals and thermal stress damage during the rewarming process. This technology has been successfully applied to the cryopreservation of large-volume cell suspensions and biological tissues.
In addition, this article reviews the main progress of cell cryopreservation in the world. It also incorporates the team’s research accumulation using multidisciplinary integration and system engineering ideas to achieve green cryopreservation, and looks forward to the future development trend of cell cryopreservation.
We believe that as an important cornerstone of life sciences and clinical medicine and the basis for cryopreservation of multi-scale life materials, cell cryopreservation has made remarkable breakthroughs, but there is still a lot of room for development and breakthroughs in its related technologies. It is very helpful to overcome the international problem of cryogenic preservation of large-scale biological materials such as tissues and organs. We call on professionals with different backgrounds in life, medicine, physics, engineering, information and chemical materials to work together to contribute to low-temperature biomedicine.
Latest developments
Over the two days, the symposium was not only a collision of ideas but also seeds sown to advance social progress in life culture. The Shandong Yinfeng Life Science Public Welfare Foundation will continue to use technology as wings and culture as roots, collaborating with all sectors of society to enhance the quality of life for the Chinese people and build a human-centered life care system.
According to recent announcements by the Jinan Municipal Bureau of Science and Technology, 11 outstanding achievements from Jinan have been included in the 2025 "Shandong Outstanding Achievements Report" project. Among them is the globally first-of-its-kind ovarian tissue dual-activation technology developed by Shandong Silver Med Life Science Research Institute (Jinan).
Recently, Frigid Zone Medicine, an authoritative international journal in the field of cryomedicine, published an important review titled "Advances in the Detection Methods for Assessing the Viability of Cryopreserved Samples". Written by the team of Yinfeng Cryomedical Research Center, the article systematically reviews and analyzes various detection techniques currently used to evaluate the viability of cryopreserved cells, tissues, and organs. It also proposes key directions from the perspectives of methodological integration and future instrument development, offering crucial theoretical support and practical guidance for the long - term cryopreservation of complex tissues and organs.
Recently, the "Novel Technology for Ultra-Low Temperature Cryopreservation, Activation, and Transplantation of Human Ovarian Tissue," developed through a collaborative effort between Shandong Yinfeng Life Science Research Institute and Beijing University of Chinese Medicine Shenzhen Hospital, has been awarded the 2025 Shandong Refrigeration and Air Conditioning Science and Technology Award. This groundbreaking technology pioneers a new pathway for female fertility preservation, marking a significant leap in China’s interdisciplinary advancements in reproductive medicine and cryobiology.
On May 19, a delegation from the Chinese Training Workshop for Government Officials of Developing Countries visited the exhibition hall of Yinfeng Biological Group's Cryomedicine Research Center. Government officials from multiple countries gained in-depth insights into Yinfeng’s innovative achievements in cryobiomedicine, cell storage, genetic technology, and other fields. They engaged in discussions with the delegation on technology transfer and international cooperation, contributing to the building of a global community with a shared future for humanity.
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