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Scientists Achieve Functional "Revival" of Mouse Brain Tissue After Rewarming from -196°C Freezing First Successful Revival of Frozen Brain! Mouse brain tissue regains memory function after being frozen at -196°C and rewarmed

2026/03/16

In science fiction, human cryopreservation and resuscitation are often regarded as a "time capsule" to the future. Now, this concept has achieved a milestone breakthrough in the laboratory—scientists have for the first time successfully cryopreserved adult mouse brain slices in liquid nitrogen at -196°C and restored multiple key neural functions, including learning and memory mechanisms, after rewarming. This achievement blazes a brand-new trail for basic neuroscience research and organ preservation technology.

Good News! Three Organoid Cryopreservation Technologies of Our Team Accepted for National Patents

2025/08/15

In the era of rapid development of organoid research, achieving long - term stable preservation while maintaining biological activity and functional integrity remains a crucial bottleneck restricting the clinical translation of this technology and its application in drug R & D. Recently, three technological inventions by the research team of Yinfeng Low - Temperature Medical Research Center were accepted by the National Intellectual Property Administration. These three technologies focus on the challenges of organoid cryopreservation and cover the key steps in the entire process of organoid vitrification preservation, offering a more efficient and reliable solution for safeguarding biological samples in organoid research.

The World's First In - Vitro Dual Activation Technology for Primitive Follicles: A Baby Born after Intra - operative Ovarian Tissue Freeze - Thaw Transplantation

2025/07/03

On June 25, 2025, the team led by Professor Wang Huiying and Dr. Jin Bo from Shenzhen Hospital of Beijing University of Chinese Medicine collaborated with Shandong Yinfeng Life Science Research Institute to develop the "ovarian dual activation" technology. Through this technology, patients with POI (primary ovarian insufficiency) underwent intra - operative freeze - thaw activation of ovarian tissue. After intra - operative transplantation, a baby was born, and both the mother and the baby are healthy and safe.

Significant Achievements: Successfully Cultivated Human Heart in Pigs, Bringing New Hope for Organ Transplantation

2025/06/19

Recently, the world's top - tier academic journal Nature featured a major research achievement by Chinese scientists on its front - page headlines. For the first time, a heart containing human cells was cultivated in a pig embryo, and this heart could beat autonomously and survived for 21 days. This groundbreaking progress offers a brand - new solution to the global shortage of organ transplants and marks a new stage in the development of xenogeneic organ cultivation technology.

2026-03-24

Breakthrough "Freeze-and-Print" Technology Debuts: Novel Cryo-Bioink Solves the Challenge of Preserving Adherent Cells

The advent of the CAMP platform means that in the future, we may be able to "retrieve" pre-prepared cell-laden bioinks from cell banks as easily as taking out an ice cube, revive them, and immediately use them for 3D printing to construct tissue engineering scaffolds or even organ chips. This breakthrough technology offers a highly promising "ready-to-use" solution for the urgent repair of large tissue defects and the rapid fabrication of personalized implants in clinical settings, with the potential to completely bridge the critical gap from laboratory to operating room.

2026-03-24

"Reviving" Life on a Computer: The First Complete 4D Full-Cycle Simulation of a Minimal Genome Cell

Nonetheless, this newly opened window not only allows us to understand how the simplest form of life operates but also paves the way for simulating more complex human cells in the future.

2026-03-16

Unlocking the Heart's Code: Scientists Discover the Regenerative Seeds to Rejuvenate the Adult Heart

Professor Wang Wei emphasized that this study clarifies the mechanism of the decline in cardiac regeneration at the cellular subpopulation level, providing a brand-new target for myocardial regenerative therapy after MI. Although clinical application still needs to bridge the gap from basic research to translational medicine, this beam of scientific light has illuminated the path to recovery for tens of millions of MI patients.

2026-03-16

Scientists Achieve Functional "Revival" of Mouse Brain Tissue After Rewarming from -196°C Freezing First Successful Revival of Frozen Brain! Mouse brain tissue regains memory function after being frozen at -196°C and rewarmed

In science fiction, human cryopreservation and resuscitation are often regarded as a "time capsule" to the future. Now, this concept has achieved a milestone breakthrough in the laboratory—scientists have for the first time successfully cryopreserved adult mouse brain slices in liquid nitrogen at -196°C and restored multiple key neural functions, including learning and memory mechanisms, after rewarming. This achievement blazes a brand-new trail for basic neuroscience research and organ preservation technology.

2026-03-04

Yinfeng Life Science Research Institute, in Collaboration with University of Science and Technology of China, Develops CryoSIM Platform, Published in Top Analytical Chemistry Journal Revolutionizing Oocyte Membrane Permeability Analysis Technology

The team successfully developed the CryoSIM platform, an intelligent microfluidics and deep learning-integrated system. This platform deeply integrates core technologies of deep learning and microfluidics to enable high-throughput, high-precision automated analysis of oocyte membrane permeability. It provides a novel technological tool for optimizing and advancing the clinical translation of oocyte cryopreservation techniques. Additionally, it offers an innovative practical paradigm for the application of artificial intelligence in low-temperature biomedicine and reproductive medicine.

2026-02-25

[World First] Pig Liver "Saves" Patient, China Achieves Another Major Breakthrough in Xenotransplantation Technology

Recently, Xijing Hospital of the Air Force Medical University announced that a team led by Academician Dou Kefeng, in collaboration with the First Affiliated Hospital of Sun Yat-sen University, Tangdu Hospital of the Air Force Medical University, and Sichuan Zhongke Aoger Biotechnology Co., Ltd., successfully completed the world's first surgery using "gene-edited pig liver extracorporeal perfusion" to treat a patient with liver failure. According to a technological novelty search, this procedure has no precedent internationally, marking another milestone breakthrough in the field of clinical xenotransplantation in China.

2026-01-26

Breaking the Spinal Cord Repair Bottleneck: Novel Bio-3D Printing Technology Enables Functional Neural Regeneration

Once considered an irreversible "forbidden zone," the spinal cord is now gradually overcoming this cognitive barrier with the advent of NEAT technology. Harnessing the power of science and technology, more patients who have lost mobility due to neural injuries may one day see the dawn of regaining their ability to stand and live independently.

2026-01-26

Brain-on-a-Chip Model Constructed from Cryopreserved Human Brain Microvasculature Facilitates Brain Disease Research and Drug Testing

This research advances the intersection of bioengineering and neuroscience. The constructed "human cerebral vascular chip" represents the first comprehensive simulation of the human cerebral vascular system from structure to function. It provides an unprecedented in vitro platform for exploring cerebral blood flow regulation, BBB mechanisms, and brain diseases closely related to vasculature, such as neuroinflammation, Alzheimer's disease, and stroke.

2026-01-19

Chinese Team Publishes Revolutionary New Cancer Strategy in Nature: Developing a Novel Cancer Vaccine

Published in Nature, this research marks a shift in tumor immunotherapy from “target blockade” to “cellular fate reprogramming.” With ongoing optimization and clinical exploration of the iVAC platform, it holds promise as a core tool for the next generation of immunotherapies, offering new hope to millions of cancer patients.

2025-12-19

Scientists Crack the "Xenogeneic Barrier", Offering a New Path for Growing Human Organs in Animals​

For a long time, human cells have often been excluded and struggled to survive in animal embryos due to the "xenogeneic barrier." The mainstream strategy in the past involved genetically engineering human cells to enhance their anti-apoptotic capabilities, but this approach carries potential safety risks such as carcinogenesis. How can this barrier be overcome more safely? A collaborative team led by the University of Texas Southwestern Medical Center and BGI Research used mice as a model to tackle this issue and achieved a critical breakthrough.

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