Major Breakthrough in Artificial Liver Research
Release time:
2024-07-30
Recently, the liver surgery team at Peking Union Medical College Hospital, in collaboration with several research institutions, has achieved a significant breakthrough in the field of artificial liver research. The research team successfully constructed a novel artificial liver with hepatic vein structures (HEALs) and a liver tissue model with enhanced activity and functional advantages using suspension printing technology and holographic lattice acoustic tweezer technology. This provides a new potential pathway for liver transplant alternatives, making tissue engineering technologies faster and more efficient. The related research findings have been published in the journal "Biomaterials."
One significant achievement of this study is the successful printing of HEALs with venous structures based on a "omnidirectional suspended printing matrix network" supporting medium. Compared to traditional 3D printed livers, HEALs not only achieve centimeter-level tissue construction but also show significant advantages in liver function expression and vascular regeneration after transplantation, making them promising for drug screening, basic research, and liver transplant replacements.
Another important achievement is the collaboration with other research institutions to optimize and utilize holographic lattice acoustic tweezer technology to construct an in vitro biomimetic 3D liver model. Primary hepatocytes subjected to holographic lattice acoustic tweezers can generate a large number of self-assembling hepatocyte spheroids within one minute. The speed is fast, and after in vitro culture, the diameters of the hepatocyte spheroids significantly increase, with substantial enhancements in core functions such as protein synthesis metabolism, glucose metabolism, and detoxification.
The research team stated that the holographic lattice acoustic tweezer technology, with its unique advantages of being non-contact, non-damaging, precise, flexible, and rapid in patterning processes, shows great potential in constructing in vitro 3D models.
Previous article
Latest developments
On August 23, the Jinan Private Economic Development Bureau and China Economic Weekly jointly launched the theme publicity activity of "Central Media Look at Jinan - Entering Jinan's Private Economy" in Yinfeng Biotechnology Park.
Led by Anhui Medical University and participated by Yinfeng Cryogenic Medical Technology Co., Ltd., the "Engineering Research Center for Life Resources Conservation and Artificial Organs of the Ministry of Education" was officially accepted and awarded by the Ministry of Education. As one of the four major platforms for the transformation of the center's project, Yinfeng Cryogenic Co., Ltd. is responsible for the "development, promotion and application of cryogenic preservation technology of biological matrix materials".
On March 28, 2023, the kick-off meeting of the International Alliance for Life Extension Research was held in Jinan, Shandong. The "International Alliance for Life Extension Research" was initiated by Shandong Yinfeng Life Science Research Institute, and jointly established by 13 international scientific research institutions engaged in the field of cryogenic biomedicine from North America, Europe, Oceania, etc., and appeared at the conference through online and offline forms.
Yinfeng Life Continuation Plan
Address: Yinfeng Biotechnology Park, 1758 Gangyuan 6th Road, High-tech Zone, Jinan City, Shandong Province
Zip Code: 250102
Telephone: 0086-0531-88897351
Mobile: 0086-19953155507
Mobile website
Official WeChat Public Number
Links:Red Cross Society of China丨Shandong Red Cross Society丨Shandong Provincial Health Commission | Yinfeng Group| Yinfeng Biological Group
All rights reserved©Yinfeng Life Continuation Powered by www.300.cn SEO
