Yinfeng Institute’s Ovarian Tissue Cryopreservation Technology Wins Shandong Refrigeration and Air Conditioning Science and Technology Award
Release time:
2025-05-27
Recently, the "Novel Technology for Ultra-Low Temperature Cryopreservation, Activation, and Transplantation of Human Ovarian Tissue," developed through a collaborative effort between Shandong Yinfeng Life Science Research Institute and Beijing University of Chinese Medicine Shenzhen Hospital, has been awarded the 2025 Shandong Refrigeration and Air Conditioning Science and Technology Award. This groundbreaking technology pioneers a new pathway for female fertility preservation, marking a significant leap in China’s interdisciplinary advancements in reproductive medicine and cryobiology.
The research team innovatively combined in vitro activation of primordial follicles (IVA) with cytokine extraction from autologous venous blood (PFC) to establish a safe and effective method for activating dormant follicles. This breakthrough offers personalized treatment for patients with premature ovarian insufficiency (POI) and poor ovarian response (POR), achieving the world’s first successful case of natural pregnancy in a patient with ovarian failure.
The team’s IVA technology involves extracting a small piece of ovarian cortical tissue via laparoscopic surgery, followed by low-temperature activation in vitro and subsequent in situ transplantation within approximately one hour. This process transforms atrophied ovarian tissue into a softer, rejuvenated state. Postoperative evaluations demonstrated improvements in ovarian volume, follicle count, ovarian artery blood flow, and normalized hormone levels. The technology also provides fertility preservation options for cancer patients.
This achievement, born from the ingenuity of Chinese scientists, not only brings new hope to families but also highlights China’s innovative prowess in life sciences and cryomedicine. Where cutting-edge technology meets the miracle of life, this breakthrough stands as a national milestone in humanity’s fight against fertility challenges.
Building on this recognition, Yinfeng’s cryomedicine team will collaborate with research institutions to accelerate the development of a comprehensive "cryopreservation-rewarming-transplantation" technological ecosystem, advancing the application of cryogenic technologies for human health.
Background: Launched in 2024 by the Shandong Association of Refrigeration, the Shandong Refrigeration and Air Conditioning Science and Technology Award honors individuals and organizations for innovative contributions to refrigeration and air conditioning technologies, including pioneering research, technological development, and the promotion of scientific achievements. The award has played a vital role in advancing technological progress and innovation within the province’s refrigeration and air conditioning industry.
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Recently, the "Novel Technology for Ultra-Low Temperature Cryopreservation, Activation, and Transplantation of Human Ovarian Tissue," developed through a collaborative effort between Shandong Yinfeng Life Science Research Institute and Beijing University of Chinese Medicine Shenzhen Hospital, has been awarded the 2025 Shandong Refrigeration and Air Conditioning Science and Technology Award. This groundbreaking technology pioneers a new pathway for female fertility preservation, marking a significant leap in China’s interdisciplinary advancements in reproductive medicine and cryobiology.
On May 19, a delegation from the Chinese Training Workshop for Government Officials of Developing Countries visited the exhibition hall of Yinfeng Biological Group's Cryomedicine Research Center. Government officials from multiple countries gained in-depth insights into Yinfeng’s innovative achievements in cryobiomedicine, cell storage, genetic technology, and other fields. They engaged in discussions with the delegation on technology transfer and international cooperation, contributing to the building of a global community with a shared future for humanity.
On the morning of May 17, 2025, an immersive exploration into life sciences and cryomedicine concluded successfully at Jinan Yinfeng Biological Science Park. Hosted by the Shandong Yinfeng Life Science Research Institute, this event offered members a firsthand look into the research base through activities such as ultra-low temperature cryotherapy experiences, brainwave signal acquisition system trials, and expert panel discussions. Participants witnessed the infinite possibilities that cryogenic technology and life sciences hold for humanity.
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In January 2025, members of the Yinfeng cryomedicine team actively participated in the "Sino-French Aerial Emergency Medical Rescue Training" and obtained certification. This signifies a further enhancement of the team's professional capabilities in the field of international emergency medical rescue.
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