Good News! Three Organoid Cryopreservation Technologies of Our Team Accepted for National Patents
Release time:
2025-08-15
In the era of rapid development of organoid research, achieving long - term stable preservation while maintaining biological activity and functional integrity remains a crucial bottleneck restricting the clinical translation of this technology and its application in drug R & D. Recently, three technological inventions by the research team of Yinfeng Low - Temperature Medical Research Center were accepted by the National Intellectual Property Administration. These three technologies focus on the challenges of organoid cryopreservation and cover the key steps in the entire process of organoid vitrification preservation, offering a more efficient and reliable solution for safeguarding biological samples in organoid research.
[Patent 1] A Raman - Spectroscopy - Monitored Method for Organoid Vitrification Preservation
The core of this invention is a Raman - compatible quartz microfluidic chip, paired with a Raman spectral detection module, a temperature control system (a Raman - compatible hot - cold stage), and a fluid control module. It is an integrated system and optimized method for organoid vitrification preservation, encompassing processes such as cryoprotectant loading, cooling, rewarming, and cryoprotectant removal. The aim is to minimize potential damages during vitrification, including osmotic, toxic, and ice - crystal - related damages, thus enabling high - viability and high - consistency organoid preservation.
[Patent 2] A Method for Vitrification Preservation and Resuscitation of Retinal Organoids
This invention presents an efficient approach for the vitrification preservation and resuscitation of retinal organoids. The research team enhanced the cryoprotectant composition, refined the loading and removal methods, and carefully selected cryopreservation carriers to achieve high - quality preservation of retinal organoids. Compared with existing techniques, this method features a lower vitrification concentration, faster recovery of retinal organoids, and complete preservation of their structural and functional integrity. It enables high - throughput, efficient, and straightforward freezing and resuscitation of retinal organoids to meet application requirements.
[Patent 3] A Static - Magnetic - Field - Assisted Organoid Freezing Device and Organoid Freezing and Thawing Method
Addressing critical issues in current organoid cryopreservation, such as ice - crystal damage, oxidative stress, and loss of function, this invention offers a static - magnetic - field - assisted organoid freezing device and a corresponding freezing and thawing method. It allows for precise magnetic - field regulation and covers the entire cryopreservation - storage - resuscitation process. Notably, an external magnetic - field - generating coil during the thawing phase can effectively inhibit recrystallization during rewarming.
The acceptance of these three patents signifies the further strengthening of our company's technological barriers in the field of organoid cryopreservation. In the future, we will continue to focus on biological sample preservation technology, expedite the transformation of innovative achievements, and provide more reliable sample support for regenerative medicine, drug R & D, and precision medicine.
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