The World's First In - Vitro Dual Activation Technology for Primitive Follicles: A Baby Born after Intra - operative Ovarian Tissue Freeze - Thaw Transplantation
Release time:
2025-07-03
On June 25, 2025, the team led by Professor Wang Huiying and Dr. Jin Bo from Shenzhen Hospital of Beijing University of Chinese Medicine collaborated with Shandong Yinfeng Life Science Research Institute to develop the "ovarian dual activation" technology. Through this technology, patients with POI (primary ovarian insufficiency) underwent intra - operative freeze - thaw activation of ovarian tissue. After intra - operative transplantation, a baby was born, and both the mother and the baby are healthy and safe.
Currently, many factors such as advanced age, lifestyle habits, and work pressure of couples planning to have children are intertwined, causing them to struggle on the path to parenthood. Especially for patients with severely diminished ovarian function, they often find themselves in an awkward situation with no available eggs. Even with the most advanced in - vitro fertilization (IVF) technology, these patients often face insurmountable difficulties.
The reproductive team at Shenzhen Hospital of Beijing University of Chinese Medicine is dedicated to creating a diagnosis and treatment system integrating traditional Chinese and Western medicine for patients with ovarian function decline and developing a series of reproductive technologies with independent intellectual property rights to relieve patients' suffering. As an inheritor of intangible cultural heritage in traditional Chinese medicine, Wang Huiying has been engaged in traditional Chinese medicine - related reproductive work for over two decades and is known as the "Goddess of Fertility". Dr. Jin Bo has studied in Japan and the United States for more than ten years and has been deeply involved in original research on assisted reproductive technologies for over 20 years, especially in the research and clinical application of new vitrification and freezing technologies for eggs and ovarian tissues. After the "Three - Famous - Doctors Project" team led by the well - known national traditional Chinese medicine expert Professor You Zhaoling joined the Department of Gynecology in the Reproductive Health Medicine Department of the hospital, the team's ability to tackle difficult and complicated cases in advanced - age reproduction has been significantly enhanced. This milestone achievement is the result of the joint efforts of all team members.
Primitive Follicle Activation Technology
Patients with severely diminished ovarian function often show no follicle development. The entire ovary is like an iceberg in the sea, with follicles "sleeping" in a dormant state. These dormant follicles are insensitive to external hormones. Strategies for assisted reproduction, such as hormone - stimulated induction of multiple follicle development, are only effective for growing follicles, not for dormant primitive follicles. This means that it is difficult for these patients to use IVF technology for pregnancy. As a result, many patients either give up treatment or choose egg donation.
Primitive follicle activation simply refers to the process of awakening primitive follicles from their dormant state to the growth stage through technical means. In recent years, foreign reports have shown that the in - vitro activation (IVA) technology for primitive follicles provides an innovative treatment option for patients with POI. Although this technology brings hope to patients with ovarian insufficiency, there is still much room for improvement in clinical efficacy, including the activation and transplantation techniques. This is also the reason why the team from Beijing University of Chinese Medicine has been exploring and developing original Chinese technologies based on decades of technical accumulation.
The ovaries, though small and unassuming, serve as the "bank" and "growth base" for eggs, shouldering the important responsibilities of women's health and human reproduction. However, the depletion of ovarian reserves and the decline in quality are objective facts. Despite the extension of human lifespan with the advancement of medical technology, the child - bearing age has not changed. New technologies can reverse the rapid decline in fertility within the child - bearing age, opening a new window of opportunity for those hoping to have children.
Latest developments
According to the latest announcement from the International Society of Cryobiology, Professor Xu Yi from the School of Health Science and Engineering at the University of Shanghai for Science and Technology, and a member of the Yinfeng Cryomedicine Expert Committee, has been elected as a Board Governor of the Society for a three-year term (2026–2028). The election was conducted through a democratic vote by all members worldwide, with three new Board Governors elected. Professor Xu Yi is the only scholar from Asia elected to the Society’s Board of Governors this time and the third elected scholar from mainland China in the Society’s 60-year history.
The significance of life extension lies not only in technological breakthroughs but also in the shared belief of every individual who believes in "a better future." With faith as their torch, these fellow travelers join hands, pooling their strength to stride forward together. We firmly believe that as this steadfast support converges into a powerful force, it will propel the Yinfeng Life Extension Plan to gain broader attention, inject continuous momentum into the development of cryobiomedicine, and illuminate the next chapter of human civilization.
Over the two days, the symposium was not only a collision of ideas but also seeds sown to advance social progress in life culture. The Shandong Yinfeng Life Science Public Welfare Foundation will continue to use technology as wings and culture as roots, collaborating with all sectors of society to enhance the quality of life for the Chinese people and build a human-centered life care system.
According to recent announcements by the Jinan Municipal Bureau of Science and Technology, 11 outstanding achievements from Jinan have been included in the 2025 "Shandong Outstanding Achievements Report" project. Among them is the globally first-of-its-kind ovarian tissue dual-activation technology developed by Shandong Silver Med Life Science Research Institute (Jinan).
Recently, Frigid Zone Medicine, an authoritative international journal in the field of cryomedicine, published an important review titled "Advances in the Detection Methods for Assessing the Viability of Cryopreserved Samples". Written by the team of Yinfeng Cryomedical Research Center, the article systematically reviews and analyzes various detection techniques currently used to evaluate the viability of cryopreserved cells, tissues, and organs. It also proposes key directions from the perspectives of methodological integration and future instrument development, offering crucial theoretical support and practical guidance for the long - term cryopreservation of complex tissues and organs.
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