The World's First In - Vitro Dual Activation Technology for Primitive Follicles: A Baby Born after Intra - operative Ovarian Tissue Freeze - Thaw Transplantation
Release time:
2025-07-03
On June 25, 2025, the team led by Professor Wang Huiying and Dr. Jin Bo from Shenzhen Hospital of Beijing University of Chinese Medicine collaborated with Shandong Yinfeng Life Science Research Institute to develop the "ovarian dual activation" technology. Through this technology, patients with POI (primary ovarian insufficiency) underwent intra - operative freeze - thaw activation of ovarian tissue. After intra - operative transplantation, a baby was born, and both the mother and the baby are healthy and safe.
Currently, many factors such as advanced age, lifestyle habits, and work pressure of couples planning to have children are intertwined, causing them to struggle on the path to parenthood. Especially for patients with severely diminished ovarian function, they often find themselves in an awkward situation with no available eggs. Even with the most advanced in - vitro fertilization (IVF) technology, these patients often face insurmountable difficulties.
The reproductive team at Shenzhen Hospital of Beijing University of Chinese Medicine is dedicated to creating a diagnosis and treatment system integrating traditional Chinese and Western medicine for patients with ovarian function decline and developing a series of reproductive technologies with independent intellectual property rights to relieve patients' suffering. As an inheritor of intangible cultural heritage in traditional Chinese medicine, Wang Huiying has been engaged in traditional Chinese medicine - related reproductive work for over two decades and is known as the "Goddess of Fertility". Dr. Jin Bo has studied in Japan and the United States for more than ten years and has been deeply involved in original research on assisted reproductive technologies for over 20 years, especially in the research and clinical application of new vitrification and freezing technologies for eggs and ovarian tissues. After the "Three - Famous - Doctors Project" team led by the well - known national traditional Chinese medicine expert Professor You Zhaoling joined the Department of Gynecology in the Reproductive Health Medicine Department of the hospital, the team's ability to tackle difficult and complicated cases in advanced - age reproduction has been significantly enhanced. This milestone achievement is the result of the joint efforts of all team members.
Primitive Follicle Activation Technology
Patients with severely diminished ovarian function often show no follicle development. The entire ovary is like an iceberg in the sea, with follicles "sleeping" in a dormant state. These dormant follicles are insensitive to external hormones. Strategies for assisted reproduction, such as hormone - stimulated induction of multiple follicle development, are only effective for growing follicles, not for dormant primitive follicles. This means that it is difficult for these patients to use IVF technology for pregnancy. As a result, many patients either give up treatment or choose egg donation.
Primitive follicle activation simply refers to the process of awakening primitive follicles from their dormant state to the growth stage through technical means. In recent years, foreign reports have shown that the in - vitro activation (IVA) technology for primitive follicles provides an innovative treatment option for patients with POI. Although this technology brings hope to patients with ovarian insufficiency, there is still much room for improvement in clinical efficacy, including the activation and transplantation techniques. This is also the reason why the team from Beijing University of Chinese Medicine has been exploring and developing original Chinese technologies based on decades of technical accumulation.
The ovaries, though small and unassuming, serve as the "bank" and "growth base" for eggs, shouldering the important responsibilities of women's health and human reproduction. However, the depletion of ovarian reserves and the decline in quality are objective facts. Despite the extension of human lifespan with the advancement of medical technology, the child - bearing age has not changed. New technologies can reverse the rapid decline in fertility within the child - bearing age, opening a new window of opportunity for those hoping to have children.
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Latest developments
Recently, the "Novel Technology for Ultra-Low Temperature Cryopreservation, Activation, and Transplantation of Human Ovarian Tissue," developed through a collaborative effort between Shandong Yinfeng Life Science Research Institute and Beijing University of Chinese Medicine Shenzhen Hospital, has been awarded the 2025 Shandong Refrigeration and Air Conditioning Science and Technology Award. This groundbreaking technology pioneers a new pathway for female fertility preservation, marking a significant leap in China’s interdisciplinary advancements in reproductive medicine and cryobiology.
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