Chinese Academy of Sciences Creates Aging Atlas of Macaque Organs: Reveals "Asynchronous" Characteristics and Advances Anti-Aging Research
Release time:
2025-12-09
Recently, a research team from the Kunming Institute of Zoology, Chinese Academy of Sciences, systematically constructed a molecular aging atlas for multiple organs of non-human primates. For the first time, the study revealed that organ aging exhibits significant asynchronous characteristics, providing a novel research framework for understanding human aging patterns and mechanisms. The findings were published in the internationally authoritative journal Nature Methods, marking an important breakthrough in the field of aging biology in China.
Human aging involves the coordinated degeneration of multiple organs. However, for a long time, there has been a lack of systematic understanding regarding whether different organs age at the same rate and how such differences arise. Due to the difficulty in obtaining matched human organ samples, the scientific community urgently needs an ideal non-human primate model. The macaque, due to its high physiological, metabolic, and aging phenotypic similarities to humans, has become a key model for addressing this challenge.
Previously, a team led by Kong Qingpeng at the Kunming Institute of Zoology, based on transcriptomic studies of macaque peripheral blood, found that the aging process exhibits nonlinear characteristics. A significant aging acceleration turning point occurs around 16 to 19 years of age (equivalent to 48 to 57 years in humans), which aligns closely with key stages of human aging, further validating the macaque as a reliable research model. However, multi-omics baseline data on the natural aging of multiple organs in non-human primates remain limited.
To address this gap, the Kunming Institute of Zoology, in collaboration with the 920th Hospital of the Joint Logistics Support Force, successfully constructed a natural aging baseline atlas covering 30 major organ systems of macaques across multiple molecular dimensions. The study found significant differences in aging rates among different organs: 12 organs, including the thymus, spleen, gastrointestinal tract, kidneys, and ovaries, age more rapidly, while 11 organs, such as the brain, muscles, liver, skin, and adrenal glands, age relatively slowly. This indicates that organ aging is not uniform, and the premature aging of certain organs may dominate the overall aging process. Further mechanistic studies revealed that a decline in mRNA translation efficiency—a core cellular ability to convert mRNA into proteins—serves as a key molecular basis for asynchronous organ aging, offering new directions for targeted anti-aging interventions.
This study not only systematically summarizes the molecular changes in the natural aging of major organs in macaques but also establishes, for the first time, a baseline and reference system for multi-organ aging in non-human primates, filling a critical gap in the field. Currently, three types of omics data have been made publicly available globally and will serve as an important resource for aging research. Experts have noted that this achievement not only deepens the understanding of "why organs age asynchronously" but also enhances China's international influence in aging biology research and primate model development.
From uncovering the turning point of aging in macaques to constructing a multi-organ molecular atlas, Chinese scientists are gradually unraveling the "organ code" of aging. By using non-human primates as a mirror, this study provides critical support for understanding the nature of human aging and developing anti-aging strategies, while also contributing "Chinese wisdom" to global aging research.
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