New Breakthroughs in Cryobiomedicine: 5th Forum Highlights Organ Preservation and AI Integration
Release time:
2026-07-06
On July 4, 2026, the 5th Forum on Cryobiomedicine and Bioheat and Mass Transfer was successfully held in Shanghai. Hosted by the Institute of Biothermal Science and Technology at the University of Shanghai for Science and Technology, the forum featured invited keynote presentations and two parallel sub-forums. Covering 13 frontier directions—including cryopreservation of cells and tissues, mechanisms of bioheat and mass transfer, clinical energy therapy, and AI‑empowered cryomedicine—multiple key technologies achieved substantial progress.
New Approaches to Cryopreservation of Organs and Organoids
Long‑term organ preservation remains a worldwide challenge limiting the development of transplantation medicine. At this forum, researchers presented a precision heat transfer control technology based on thermal metamaterials, which achieves uniform regulation of the temperature field during cryopreservation by designing special thermal structures. This approach is expected to overcome the damage caused by non‑uniform heat transfer during cooling and rewarming of large‑volume specimens. Meanwhile, novel heat transfer techniques such as electromagnetic induction rapid rewarming and directional freezing have also yielded interim experimental data, offering more technological options for deep cryopreservation of complex organs like kidneys and livers. In vascular preservation, a low‑toxicity composite cryoprotectant protocol was reported, which successfully maintained the mechanical properties and endothelial integrity of 6‑mm‑diameter small arteries during vitrification. Animal transplantation experiments confirmed good postoperative patency, marking the transition of this technology from laboratory research toward clinical validation.
New Insights into Microscale Heat and Mass Transfer Mechanisms
At the fundamental research level, significant breakthroughs were achieved in mass transfer regulation at the single‑cell and microdroplet scales. By constructing an osmotic‑driven mass transfer theoretical model combined with an AI‑assisted image recognition system, the researchers realized high‑throughput and reproducible regulation of the protein crystallization microenvironment. This work deepened the understanding of cryoprotectant permeation pathways, solute diffusion, and droplet interfacial stability, providing theoretical support for microfluidic cryobiological sample processing. In addition, for oocyte cryopreservation, the researchers developed an integrated processing platform combining magnetic hydrogel encapsulation and microfluidic chips, effectively reducing the mechanical and cryoinjuries associated with conventional procedures, thus offering a safer technological path for female fertility preservation.
Deep Integration of Artificial Intelligence and Cryobiomedicine
AI technology emerged as a high‑frequency keyword at this forum. From intelligent image recognition‑assisted microdroplet manipulation, to machine learning models for predicting optimal cryoprotectant formulations, to automated control of cryopreservation processes, data‑driven intelligent transformation is reshaping traditional research paradigms. Researchers generally agree that the involvement of AI and big data will significantly enhance the efficiency and reproducibility of cryobiological experiments, accelerating the translation of key technologies from the laboratory to clinical applications.
Expanding Exploration of Cryobiological Mechanisms
At the theoretical level, presentations also covered the cryoadaptation mechanisms of extremophilic organisms, toxicity neutralization strategies for cryoprotectants, and thermophysical laws during the cryogenic phase transition of biomaterials. These studies revealed the intrinsic mechanisms of cryoinjury across molecular, cellular, and tissue levels, laying a theoretical foundation for designing safer and more efficient cryopreservation protocols. In particular, the disciplinary consensus—"making cryobiomedicine more vibrant, deepening interdisciplinary thermal physics research, and broadening the scope of applications"—further aligned the research directions and goals of the participants.
Overall Trends and Future Prospects
This forum clearly reflected that cryobiomedicine research in China is accelerating toward a full‑chain innovation pattern encompassing "mechanism exploration, technological breakthroughs, equipment development, and clinical translation." Particularly in frontier areas such as organ cryopreservation, microscale heat and mass transfer, and AI‑empowered cryomedicine, Chinese research teams have already achieved several original outcomes with international impact, significantly enhancing the overall competitiveness of the discipline. In the future, driven by the continued deepening of multidisciplinary integration and the strong pull of clinical needs, cryobiomedicine is expected to play an even more critical role in the treatment of major diseases, regenerative medicine, and fertility preservation, thereby contributing more scientific and technological strength to the Healthy China strategy.
Previous article
Previous article
Latest developments
Yinfeng Foundation Honored as "2025 Public Welfare Donor" by Jinan Red Cross
Looking ahead, Yinfeng Foundation will use this recognition as an opportunity to further deepen its strategic collaboration with the Jinan Red Cross, expand cooperation in areas such as life health and emergency response, and continue to empower efforts to accelerate the construction of a "new, strong, excellent, rich, beautiful, and high-quality" modern socialist strong capital city, contributing even more Yinfeng strength to this endeavor.
The team successfully developed the CryoSIM platform, an intelligent microfluidics and deep learning-integrated system. This platform deeply integrates core technologies of deep learning and microfluidics to enable high-throughput, high-precision automated analysis of oocyte membrane permeability. It provides a novel technological tool for optimizing and advancing the clinical translation of oocyte cryopreservation techniques. Additionally, it offers an innovative practical paradigm for the application of artificial intelligence in low-temperature biomedicine and reproductive medicine.
Public Welfare Partnership: A Special Letter from the Jinan Red Cross
On the afternoon of January 30, 2026, the Jinan Red Cross presented a letter of special significance to the Shandong Yinfeng Life Science Public Welfare Foundation (hereinafter referred to as the Yinfeng Foundation).
World’s First Achievement Highlights Brand Leadership
In the future, Yinfeng Life Science Research Institute will continue to uphold its mission of "Dedicated to Medical Technology, Safeguarding Human Health." It will empower brand building with more original and pioneering scientific and technological achievements, contributing wisdom and strength to Shandong's goal of building a national regional innovation hub and promoting Chinese brands on the global stage.
Global First Ovarian Tissue Dual Activation Technology Debuts at 2025 Jinan Achievements Conference
Currently, the ovarian tissue dual activation technology has been successfully applied in clinical practice at Beijing University of Chinese Medicine Shenzhen (Longgang) Hospital, having treated over 400 patients with a treatment success rate of 70%. Over the next three years, Shandong Yinfeng Life Science Research Institute plans to use Jinan as a center to gradually expand the transformation and application of this technological achievement nationwide.
According to the latest announcement from the International Society of Cryobiology, Professor Xu Yi from the School of Health Science and Engineering at the University of Shanghai for Science and Technology, and a member of the Yinfeng Cryomedicine Expert Committee, has been elected as a Board Governor of the Society for a three-year term (2026–2028). The election was conducted through a democratic vote by all members worldwide, with three new Board Governors elected. Professor Xu Yi is the only scholar from Asia elected to the Society’s Board of Governors this time and the third elected scholar from mainland China in the Society’s 60-year history.
Yinfeng Life Continuation Plan
Address: Yinfeng Biotechnology Park, 1758 Gangyuan 6th Road, High-tech Zone, Jinan City, Shandong Province
Zip Code: 250102
Telephone: 0086-0531-88897351
Mobile: 0086-19953155515
Mobile website
Official WeChat Public Number
Links:Red Cross Society of China丨Shandong Red Cross Society丨Shandong Provincial Health Commission | Yinfeng Group| Yinfeng Biological Group
All rights reserved©Yinfeng Life Continuation Powered by www.300.cn SEO
