Major Breakthrough in Rewarming Technology! Team Led by Former President of the International Society for Cryobiology, Gao Dayong, Develops Single-mode Electromagnetic Resonance Rewarming Technology
Release time:
2024-12-02
The 21st century is often regarded as the era of life sciences and medicine. As a vital branch of life sciences, cryobiomedicine, with its unique principles and advantages, has been extensively applied in the biomedical field. This includes the preservation of biological specimens, the creation of biobanks, drug development, and clinical treatment of diseases.
Continuous Achievements in Cryopreservation Technology
After nearly a century of development, cryobiomedicine has successfully achieved the cryopreservation and rewarming of numerous cells. At the level of tissues and organs, there have been significant breakthroughs, such as the cryopreservation and rewarming of tissues like corneas, nerves, skin, severed fingers/toes, blood vessels, ovaries, testes, bones, and tendons. Scientists are also gradually exploring cryopreservation and rewarming techniques for organs such as the heart, kidneys, and liver.
Currently, much of the fundamental research in cryobiomedicine focuses on the long-term cryogenic preservation of living biological cells, aiming to identify ideal cryoprotectants. This involves the multi-scale, comprehensive optimization and control of the entire cryopreservation process within the established cryoprotectant solution system. Vitrification is the most commonly used technique here.
The basic principle of vitrification is to solidify a high concentration of cryoprotectant in an ultra-low temperature environment, forming an irregular glass-like solid that retains normal molecular and ionic distribution from its liquid state, thus providing protection when vitrification occurs within cells. The key to vitrification is the elimination of damage caused by ice crystals. Therefore, for larger tissues, organs, and reproductive samples like embryos and eggs, vitrification is the most promising method for cryopreservation. However, even if an ideal vitrification process is implemented, once the sample is rewarmed, ice recrystallization can occur, causing irreparable harm to cells. Hence, both the cooling and rewarming processes require optimal tuning; otherwise, ice crystals may form, and the organism may experience a "frozen burn" effect. Ice can cause damage to tissues and organs due to rapid cellular rupture. Rapid and uniform rewarming is crucial to prevent fatal internal and external ice recrystallization in cells and tissues during thawing.
Urgent Development of Rapid Uniform Rewarming Technology
Another critical challenge of cryopreservation is the rewarming process. If rewarming is not swift or even, ice crystals can form, damaging tissues and organs. How to reheat biological materials from deep cryogenic temperatures back to normal body temperatures while maintaining their viability and biological functions is crucial. A new technological breakthrough has come from Gao Dayong's team at the University of Washington's Cryobiomedical Engineering and Artificial Organs Center. Their developed single-mode electromagnetic resonance (SMER) rewarming technology can rapidly and uniformly rewarm samples.
Gao Dayong
An internationally renowned scientist and leading figure in cryobiological engineering and cryopreservation.
Former president of the International Society for Cryobiology.
Permanent professor in the Departments of Mechanical Engineering and Bioengineering at the University of Washington, USA.
Specifically, the team's single-mode electromagnetic resonance rewarming is a dielectric heating method based on Maxwell's theory, which increases the temperature of non-conductive samples by placing them in a high-frequency electromagnetic field. The sample is placed in a resonant cavity with an induction coil, generating electromagnetic waves through an oscillating electric field. The main advantage of this method is the capability to achieve very rapid and uniform heating in a short time. Additionally, the team uses automatic single-mode electromagnetic waves to automate specific frequency waves and maintain stability throughout the rewarming process. They have also developed an embedded control system to monitor the proceedings within the system.
Ensuring that different parts of the frozen biological material absorb an equal amount of heat for uniform temperature rise has always been a significant challenge in the rewarming process. After years of research, Gao Dayong's team made the following optimizations: the optimized design of an electromagnetic resonance cavity that produces high-intensity standing waves, maintaining resonance throughout the heating process, preventing thermal runaway, and accurately loading the sample into the cavity. All these ensure rapid and uniform rewarming, partially addressing the issue of ice recrystallization when biological materials are rewarmed.
In interviews, the research team expressed optimism that, in the coming years, it may be possible to cryopreserve certain organs. For small mammals, expectations are placed on the next 10 years or more. However, the leap from small mammals to humans will be monumental. We eagerly anticipate the arrival of that day!
Latest developments
Recently, the "Novel Technology for Ultra-Low Temperature Cryopreservation, Activation, and Transplantation of Human Ovarian Tissue," developed through a collaborative effort between Shandong Yinfeng Life Science Research Institute and Beijing University of Chinese Medicine Shenzhen Hospital, has been awarded the 2025 Shandong Refrigeration and Air Conditioning Science and Technology Award. This groundbreaking technology pioneers a new pathway for female fertility preservation, marking a significant leap in China’s interdisciplinary advancements in reproductive medicine and cryobiology.
On May 19, a delegation from the Chinese Training Workshop for Government Officials of Developing Countries visited the exhibition hall of Yinfeng Biological Group's Cryomedicine Research Center. Government officials from multiple countries gained in-depth insights into Yinfeng’s innovative achievements in cryobiomedicine, cell storage, genetic technology, and other fields. They engaged in discussions with the delegation on technology transfer and international cooperation, contributing to the building of a global community with a shared future for humanity.
On the morning of May 17, 2025, an immersive exploration into life sciences and cryomedicine concluded successfully at Jinan Yinfeng Biological Science Park. Hosted by the Shandong Yinfeng Life Science Research Institute, this event offered members a firsthand look into the research base through activities such as ultra-low temperature cryotherapy experiences, brainwave signal acquisition system trials, and expert panel discussions. Participants witnessed the infinite possibilities that cryogenic technology and life sciences hold for humanity.
The international academic platform ScholarGPS recently announced its global lists of Highly Ranked Scholars - Lifetime and Highly Ranked Scholars - Prior 5 Years, recognizing the top 0.05% of scholars across various disciplines. Among the selected Chinese scholars are national-level talents, leading figures in specialized fields, and seasoned academics dedicated to long-term research.
In January 2025, members of the Yinfeng cryomedicine team actively participated in the "Sino-French Aerial Emergency Medical Rescue Training" and obtained certification. This signifies a further enhancement of the team's professional capabilities in the field of international emergency medical rescue.
Brands are an important symbol of high-quality development. Under the drive of strategies such as Brand Strong Province and Good Products Shandong, Shandong brands have risen to prominence. Particularly in recent years, Shandong brands have focused on new quality productivity, using "new" to enhance quality, achieving remarkable results in high-quality development.
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