A Blockbuster in Science! U.S. Discovers a Switch to Reverse Diabetes, Offering Hope for Treatment
Release time:
2025-06-13
A groundbreaking study published in the international top - tier journal Science in February this year may bring revolutionary hope to hundreds of millions of type 2 diabetes patients worldwide. The team of scientists from the University of Michigan in the United States not only uncovered a core secret of diabetes onset but, even more excitingly, they successfully reversed the damage, which may completely transform the diabetes treatment model.
The research focuses on the “energy factories” of human cells - mitochondria. Imagine a city's power plant breaking down; the whole city would fall into chaos. In the insulin - producing cells (β - cells) of diabetes patients, the mitochondria have long been abnormal, but the causes and consequences have always remained a mystery.
The University of Michigan team designed a sophisticated experiment. By disrupting three key aspects of the mitochondria (DNA, the pathway for clearing damaged mitochondria, and the pathway for maintaining the number of healthy mitochondria), they unexpectedly found that disrupting any one of these links would trigger the same catastrophic domino effect. Damaged mitochondria first activate the cell's internal “alarm system” (stress response), which leads to changes in chromatin structure. Eventually, mature and fully functional β - cells “revert to youth” and turn back into an immature state.
“This ‘rejuvenation’ is by no means a good thing,” the lead researcher explained. “It's like an experienced insulin - producing technician suddenly losing their memory and becoming an unskilled apprentice.” As a result, β - cells “forget” how to produce insulin, leading to uncontrolled blood sugar. More importantly, the same mechanism has also been confirmed in liver cells and fat cells, which explains why diabetes causes systemic metabolic disorders, such as excessive sugar production in the liver, abnormal fat accumulation, and impaired muscle function.
However, the story doesn't end in despair. The research team found that these cells didn't die but were just “disabled.” They tried using a drug called ISRIB to block the cell stress - response pathway. A miracle happened after four weeks: in the treated mice, those “amnesic” β - cells “remembered” their mission and began to secrete insulin normally, effectively controlling blood sugar. This is like giving an amnesic technician an efficient “memory awakening” to restore their core skills.
“This opens up a brand - new treatment approach,” the corresponding author of the paper emphasized. “We no longer just focus on supplementing insulin but directly target the root cause, which is to repair the cells' own functional disorders.”
Currently, the research team is making every effort to explore ways to apply this breakthrough to human patients. They are conducting in - depth analyses of the damaged cell pathways in order to develop precise repair therapies.
Although it will take time to verify the transition from laboratory results to clinical applications, this discovery by the University of Michigan has undoubtedly lit the dawn of revolutionary treatment. It not only provides a new perspective for understanding diabetes but also gives hundreds of millions of patients around the world a glimmer of hope that one day, they can regain control of their blood sugar and enjoy a healthy future by awakening the dormant memory of their own cells.
Previous article
Previous article
Latest developments
Recently, the "Novel Technology for Ultra-Low Temperature Cryopreservation, Activation, and Transplantation of Human Ovarian Tissue," developed through a collaborative effort between Shandong Yinfeng Life Science Research Institute and Beijing University of Chinese Medicine Shenzhen Hospital, has been awarded the 2025 Shandong Refrigeration and Air Conditioning Science and Technology Award. This groundbreaking technology pioneers a new pathway for female fertility preservation, marking a significant leap in China’s interdisciplinary advancements in reproductive medicine and cryobiology.
On May 19, a delegation from the Chinese Training Workshop for Government Officials of Developing Countries visited the exhibition hall of Yinfeng Biological Group's Cryomedicine Research Center. Government officials from multiple countries gained in-depth insights into Yinfeng’s innovative achievements in cryobiomedicine, cell storage, genetic technology, and other fields. They engaged in discussions with the delegation on technology transfer and international cooperation, contributing to the building of a global community with a shared future for humanity.
On the morning of May 17, 2025, an immersive exploration into life sciences and cryomedicine concluded successfully at Jinan Yinfeng Biological Science Park. Hosted by the Shandong Yinfeng Life Science Research Institute, this event offered members a firsthand look into the research base through activities such as ultra-low temperature cryotherapy experiences, brainwave signal acquisition system trials, and expert panel discussions. Participants witnessed the infinite possibilities that cryogenic technology and life sciences hold for humanity.
The international academic platform ScholarGPS recently announced its global lists of Highly Ranked Scholars - Lifetime and Highly Ranked Scholars - Prior 5 Years, recognizing the top 0.05% of scholars across various disciplines. Among the selected Chinese scholars are national-level talents, leading figures in specialized fields, and seasoned academics dedicated to long-term research.
In January 2025, members of the Yinfeng cryomedicine team actively participated in the "Sino-French Aerial Emergency Medical Rescue Training" and obtained certification. This signifies a further enhancement of the team's professional capabilities in the field of international emergency medical rescue.
Brands are an important symbol of high-quality development. Under the drive of strategies such as Brand Strong Province and Good Products Shandong, Shandong brands have risen to prominence. Particularly in recent years, Shandong brands have focused on new quality productivity, using "new" to enhance quality, achieving remarkable results in high-quality development.
Yinfeng Life Continuation Plan
Address: Yinfeng Biotechnology Park, 1758 Gangyuan 6th Road, High-tech Zone, Jinan City, Shandong Province
Zip Code: 250102
Telephone: 0086-0531-88897351
Mobile: 0086-19953155507
Mobile website
Official WeChat Public Number
Links:Red Cross Society of China丨Shandong Red Cross Society丨Shandong Provincial Health Commission | Yinfeng Group| Yinfeng Biological Group
All rights reserved©Yinfeng Life Continuation Powered by www.300.cn SEO
