-196°C Technological Breakthrough: Electrically - Driven Deep - Cryogenic Storage System ushers in a New Era of Biological Sample Storage
Release time:
2025-08-21
In the realm of biological sample storage, traditional methods relying on liquid nitrogen have long held sway. Recently, a groundbreaking world's first fully - automatic deep - cryogenic storage system, electrically driven at - 196°C, was officially put into operation at Ruijin Hospital affiliated with the School of Medicine of Shanghai Jiao Tong University, offering a novel solution for biological sample storage.
Empowered by Aerospace Technology: Initiating a New Era of Deep - Cryogenic Storage
The core technological foundation of this storage system stems from over a decade of profound accumulation in the aerospace sector. The R & D team ingeniously applied the variable - density vacuum multi - layer insulation technology, which is used by spacecraft in the extreme conditions of space, to the thermal insulation of low - temperature tanks for biological samples. This innovative approach has significantly enhanced the overall thermal insulation performance by 35%. Under the same conditions, the equipment's cold - holding time has been extended by over 50%, providing a more stable and long - lasting low - temperature environment for biological samples.
Regarding heat conduction, the team utilized the phase - change heat transfer technology employed by satellite payloads under extremely low - temperature conditions for uniform heat conduction in the evaporative gas reliquefaction device. Through this technology, the overall cooling capacity transfer efficiency has been greatly improved, ensuring that the temperature uniformity within the - 196°C environment is controlled within ±3°C, creating a uniform and stable storage environment for biological samples.
The Advantages of Pure Electric Drive: Breaking Through Traditional Storage Bottlenecks
The newly developed fully - automatic deep - cryogenic storage system at - 196°C mainly relies on a liquid - nitrogen self - circulation maintenance technology. Using liquid nitrogen as the refrigerant medium, it can maintain a deep - cryogenic environment stably over the long term with only electric drive, eliminating the need for external liquid - nitrogen refilling. This pure - electric drive mode offers remarkable advantages.
In terms of cost, compared with traditional liquid - nitrogen deep - cryogenic storage solutions, the operating costs can be reduced by 50% in the eastern coastal regions of China and even by 90% in the western plateau areas. This not only addresses the challenges of difficult liquid - nitrogen transportation, unstable supply, and insufficient hydraulic pressure in plateau regions but also provides a more cost - effective option for biological sample storage.
Moreover, the system integrates innovative designs such as on - site liquid - nitrogen production through air separation and an embedded small - scale deep - cryogenic refrigerator, achieving near - zero loss of liquid nitrogen. In terms of sample safety, the equipment can ensure that the ambient temperature remains ≤ - 190°C throughout. Even in the event of power outages or other emergencies, it can maintain the temperature in the storage space below - 135°C without external power for 15 days, establishing a solid safeguard for biological sample storage.
Intelligent Management: Efficient, Convenient, and Leading the Industry's Intelligent Development
The system also features highly intelligent management. Equipped with security measures such as facial recognition and fingerprint passwords, it ensures the safety of sample storage. The automatic inventory function continuously optimizes the storage space, and it only takes 6 seconds to retrieve a single sample tube. With the precise coordination of 894 modules, it truly realizes full - process intelligent management from storage to retrieval, significantly improving the efficiency of biological sample storage and management.
The system belongs to a diverse product portfolio, including the - 196°C fully - automatic deep - cryogenic storage system, the - 80°C fully - automatic ultra - low - temperature storage system, the iKV - DURA high - performance dry - ice bucket, the iKV - Rewake automatic cell resuscitation device, and the upcoming new freeze - thaw device, covering the entire life - cycle management of biological sample storage, preparation, and transportation.
The R & D team plans to establish a domestic industrial chain covering storage, transportation, and preparation within three years. This will break the current reliance on imported high - end life - science instruments, accelerate the application of independently developed equipment, and provide strong technological support for the development of China's biotechnology sector.
Latest developments
Recently, Frigid Zone Medicine, an authoritative international journal in the field of cryomedicine, published an important review titled "Advances in the Detection Methods for Assessing the Viability of Cryopreserved Samples". Written by the team of Yinfeng Cryomedical Research Center, the article systematically reviews and analyzes various detection techniques currently used to evaluate the viability of cryopreserved cells, tissues, and organs. It also proposes key directions from the perspectives of methodological integration and future instrument development, offering crucial theoretical support and practical guidance for the long - term cryopreservation of complex tissues and organs.
Recently, the "Novel Technology for Ultra-Low Temperature Cryopreservation, Activation, and Transplantation of Human Ovarian Tissue," developed through a collaborative effort between Shandong Yinfeng Life Science Research Institute and Beijing University of Chinese Medicine Shenzhen Hospital, has been awarded the 2025 Shandong Refrigeration and Air Conditioning Science and Technology Award. This groundbreaking technology pioneers a new pathway for female fertility preservation, marking a significant leap in China’s interdisciplinary advancements in reproductive medicine and cryobiology.
On May 19, a delegation from the Chinese Training Workshop for Government Officials of Developing Countries visited the exhibition hall of Yinfeng Biological Group's Cryomedicine Research Center. Government officials from multiple countries gained in-depth insights into Yinfeng’s innovative achievements in cryobiomedicine, cell storage, genetic technology, and other fields. They engaged in discussions with the delegation on technology transfer and international cooperation, contributing to the building of a global community with a shared future for humanity.
On the morning of May 17, 2025, an immersive exploration into life sciences and cryomedicine concluded successfully at Jinan Yinfeng Biological Science Park. Hosted by the Shandong Yinfeng Life Science Research Institute, this event offered members a firsthand look into the research base through activities such as ultra-low temperature cryotherapy experiences, brainwave signal acquisition system trials, and expert panel discussions. Participants witnessed the infinite possibilities that cryogenic technology and life sciences hold for humanity.
The international academic platform ScholarGPS recently announced its global lists of Highly Ranked Scholars - Lifetime and Highly Ranked Scholars - Prior 5 Years, recognizing the top 0.05% of scholars across various disciplines. Among the selected Chinese scholars are national-level talents, leading figures in specialized fields, and seasoned academics dedicated to long-term research.
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