3
2
1

-196°C Technological Breakthrough: Electrically - Driven Deep - Cryogenic Storage System ushers in a New Era of Biological Sample Storage

Release time:

2025-08-21

In the realm of biological sample storage, traditional methods relying on liquid nitrogen have long held sway. Recently, a groundbreaking world's first fully - automatic deep - cryogenic storage system, electrically driven at - 196°C, was officially put into operation at Ruijin Hospital affiliated with the School of Medicine of Shanghai Jiao Tong University, offering a novel solution for biological sample storage.


Empowered by Aerospace Technology: Initiating a New Era of Deep - Cryogenic Storage

The core technological foundation of this storage system stems from over a decade of profound accumulation in the aerospace sector. The R & D team ingeniously applied the variable - density vacuum multi - layer insulation technology, which is used by spacecraft in the extreme conditions of space, to the thermal insulation of low - temperature tanks for biological samples. This innovative approach has significantly enhanced the overall thermal insulation performance by 35%. Under the same conditions, the equipment's cold - holding time has been extended by over 50%, providing a more stable and long - lasting low - temperature environment for biological samples.

Regarding heat conduction, the team utilized the phase - change heat transfer technology employed by satellite payloads under extremely low - temperature conditions for uniform heat conduction in the evaporative gas reliquefaction device. Through this technology, the overall cooling capacity transfer efficiency has been greatly improved, ensuring that the temperature uniformity within the - 196°C environment is controlled within ±3°C, creating a uniform and stable storage environment for biological samples.


The Advantages of Pure Electric Drive: Breaking Through Traditional Storage Bottlenecks

The newly developed fully - automatic deep - cryogenic storage system at - 196°C mainly relies on a liquid - nitrogen self - circulation maintenance technology. Using liquid nitrogen as the refrigerant medium, it can maintain a deep - cryogenic environment stably over the long term with only electric drive, eliminating the need for external liquid - nitrogen refilling. This pure - electric drive mode offers remarkable advantages.

In terms of cost, compared with traditional liquid - nitrogen deep - cryogenic storage solutions, the operating costs can be reduced by 50% in the eastern coastal regions of China and even by 90% in the western plateau areas. This not only addresses the challenges of difficult liquid - nitrogen transportation, unstable supply, and insufficient hydraulic pressure in plateau regions but also provides a more cost - effective option for biological sample storage.

Moreover, the system integrates innovative designs such as on - site liquid - nitrogen production through air separation and an embedded small - scale deep - cryogenic refrigerator, achieving near - zero loss of liquid nitrogen. In terms of sample safety, the equipment can ensure that the ambient temperature remains ≤ - 190°C throughout. Even in the event of power outages or other emergencies, it can maintain the temperature in the storage space below - 135°C without external power for 15 days, establishing a solid safeguard for biological sample storage.


Intelligent Management: Efficient, Convenient, and Leading the Industry's Intelligent Development

The system also features highly intelligent management. Equipped with security measures such as facial recognition and fingerprint passwords, it ensures the safety of sample storage. The automatic inventory function continuously optimizes the storage space, and it only takes 6 seconds to retrieve a single sample tube. With the precise coordination of 894 modules, it truly realizes full - process intelligent management from storage to retrieval, significantly improving the efficiency of biological sample storage and management.

The system belongs to a diverse product portfolio, including the - 196°C fully - automatic deep - cryogenic storage system, the - 80°C fully - automatic ultra - low - temperature storage system, the iKV - DURA high - performance dry - ice bucket, the iKV - Rewake automatic cell resuscitation device, and the upcoming new freeze - thaw device, covering the entire life - cycle management of biological sample storage, preparation, and transportation.

 

The R & D team plans to establish a domestic industrial chain covering storage, transportation, and preparation within three years. This will break the current reliance on imported high - end life - science instruments, accelerate the application of independently developed equipment, and provide strong technological support for the development of China's biotechnology sector.
 

Latest developments

【The YinFeng Life Continuation Project Debuts at the 2026 Annual Meeting of the Chinese Medical Association's Medical Ethics Branch—Ethics Leading Biotech Toward Benevolent Innovation】

The debut and discourse of the YinFeng Life Continuation Project not only served as an authoritative demonstration of its own ethical governance framework but also contributed practical wisdom toward establishing industry norms.

Yinfeng Foundation Honored as "2025 Public Welfare Donor" by Jinan Red Cross

Looking ahead, Yinfeng Foundation will use this recognition as an opportunity to further deepen its strategic collaboration with the Jinan Red Cross, expand cooperation in areas such as life health and emergency response, and continue to empower efforts to accelerate the construction of a "new, strong, excellent, rich, beautiful, and high-quality" modern socialist strong capital city, contributing even more Yinfeng strength to this endeavor.

Yinfeng Life Science Research Institute, in Collaboration with University of Science and Technology of China, Develops CryoSIM Platform, Published in Top Analytical Chemistry Journal Revolutionizing Oocyte Membrane Permeability Analysis Technology

The team successfully developed the CryoSIM platform, an intelligent microfluidics and deep learning-integrated system. This platform deeply integrates core technologies of deep learning and microfluidics to enable high-throughput, high-precision automated analysis of oocyte membrane permeability. It provides a novel technological tool for optimizing and advancing the clinical translation of oocyte cryopreservation techniques. Additionally, it offers an innovative practical paradigm for the application of artificial intelligence in low-temperature biomedicine and reproductive medicine.

Public Welfare Partnership: A Special Letter from the Jinan Red Cross

On the afternoon of January 30, 2026, the Jinan Red Cross presented a letter of special significance to the Shandong Yinfeng Life Science Public Welfare Foundation (hereinafter referred to as the Yinfeng Foundation).

World’s First Achievement Highlights Brand Leadership

In the future, Yinfeng Life Science Research Institute will continue to uphold its mission of "Dedicated to Medical Technology, Safeguarding Human Health." It will empower brand building with more original and pioneering scientific and technological achievements, contributing wisdom and strength to Shandong's goal of building a national regional innovation hub and promoting Chinese brands on the global stage.

Global First Ovarian Tissue Dual Activation Technology Debuts at 2025 Jinan Achievements Conference

Currently, the ovarian tissue dual activation technology has been successfully applied in clinical practice at Beijing University of Chinese Medicine Shenzhen (Longgang) Hospital, having treated over 400 patients with a treatment success rate of 70%. Over the next three years, Shandong Yinfeng Life Science Research Institute plans to use Jinan as a center to gradually expand the transformation and application of this technological achievement nationwide.