Exploring the Mysteries of the Human Brain Adds a New Model: Chinese Scientists Successfully Create Spinal Trigeminal
Release time:
2024-10-21
Nucleus Organoids Neuroscience, a brilliant gem in the life sciences, is leading us to delve into the mysteries of the human brain, paving new paths for treating brain diseases and advancing artificial intelligence. In the past, scientists mainly relied on model animals and two-dimensional cell cultures to unveil the secrets of the brain. However, the advent of brain organoids is like a beacon illuminating the journey of exploration.
According to the latest report by China News Service, Xiang Yangfei's research team from the School of Life Science and Technology at ShanghaiTech University has announced a groundbreaking success in constructing human brain organoids specific to the spinal trigeminal nucleus (SpV) and building an in vitro model of inter-brain connection associated with it. This innovation is not only the first of its kind in China but also provides a new perspective and tool for global brain science research.
The SpV, a "giant" cranial nerve nucleus located in the medulla, plays a critical role in receiving sensory information from the craniofacial region and transmitting it to the thalamus. Despite its close connection to normal physiological functions and multiple pathological mechanisms in the human body, there has been a lack of human-derived research models targeting the SpV until now. Xiang Yangfei's team successfully simulated the characteristics and functions of the SpV by finely regulating the three-dimensional neural differentiation of human pluripotent stem cells in vitro.
During the long-term cultivation process, researchers were pleasantly surprised to find that SpV neurons spontaneously formed axonal bundle structures in the organoids, suggesting their potential projection abilities. This discovery undoubtedly provides valuable model resources for studying the development of human brain nuclei, neural targeting projection, and related pathological mechanisms.
Brain organoids, the "mini-brains," have demonstrated their unique value in various fields such as brain development, hereditary brain diseases, neurodegenerative diseases, brain evolution, regenerative medicine, brain tumors, and pathogen infections. Although they cannot completely replace the real human brain, significant strides have been made in recreating the intricate structure and developmental process of brain tissues in vivo.
Xiang Yangfei emphasized that every technological advance is a brave exploration of the unknown. The SpV-specific human brain organoids they constructed represent another solid step toward uncovering the mysteries of the human brain. With the continuous development and improvement of technology, it is believed that we can gain a deeper understanding of the human brain, contributing more wisdom and strength to human health and well-being in the future.
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