Cryopreservation Technology of Human Tissues and Organs
At normal temperature, isolated ischemic tissues and organs die in a short period of time (a few minutes, many less than a few hours) and cannot be used for transplantation. It is impossible to complete the transplant in such a short time. Therefore, it is necessary to preserve the activity of tissues and organs by cryopreservation technology. At present, the preservation of tissues and organs mainly adopts the technique of perfusing the cryoprotectant of infiltrating organs and then lowering the temperature by program. The principle is to slow down the rate of the chemical reactions such as hypoxia and energy consumption, so as to avoid chemical and physical damage caused by chemical reaction and ice crystal, keep their biological activity, thus prolong the survival time of isolated tissues and organs.
Through in-depth research, some human tissues and organs cryopreservation and resuscitation technology (including cornea, valve, tendon, joint, blood vessel, skin, ovary, small-sized broken limb) and corresponding irrigation solution and cryoprotectant components have been developed to realize the short-term, medium-term and long-term preservation of various tissues and organs in accordance with clinical transplantation under different low-temperature environment, so as to break the limitation of time and region on tissue and organ transplantation.
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