Hard-won! my country’s first “frozen baby” undergoes health review
Release time:
2021-11-04
Recently, Beijing Obstetrics and Gynecology Hospital welcomed a special baby. This is the first child in China to become pregnant naturally after a successful transplant of cryopreserved ovarian tissue. The 45-day re-examination results showed that all indicators of the baby were normal and everything was healthy!
Background information
Ovarian tissue cryopreservation transplantation is to remove part of the patient's ovaries and freeze them. After the patient recovers, the frozen ovarian tissue will be transplanted back into the body. In this way, the patient's fertility and normal ovarian function can be extended for 10, 20 or even 30 years.
Success!
Two-year frozen ovarian tissue returned to mother's body to give birth to healthy baby
Holding her sleeping child in her arms, Ms. Li arrived at the 13th floor of the ward building of Beijing Obstetrics and Gynecology Hospital and opened the door of Ruan Xiangyan's office. "Director, the child is very healthy during the review. Look at the examination sheet. He is 54.5 centimeters tall and weighs 4720 grams!"
Ruan Xiangyan and Ms. Li
Ms. Li is the first patient in China to have a natural pregnancy after cryopreserved ovarian tissue transplantation. Five years ago, she made the decision to undergo cryopreservation of ovarian tissue here.
In April 2016, Ms. Li was diagnosed with myelodysplastic syndrome, and bone marrow transplantation was the only cure. However, the high-dose chemotherapy before the transplant will seriously damage her ovarian function, and she may lose the chance of becoming a mother forever.
At that time, Ms. Li was only 29 years old, and the news kept her awake all night. For this situation, the most common method is to freeze eggs. However, Ms. Li, whose physical condition is already in poor condition, still has no available mature eggs after two weeks of ovulation induction injections. Inadvertently, Ms. Li learned that "the obstetrics and gynecology hospital is conducting an experiment on ovarian tissue cryopreservation."
On September 25, 2016, before chemotherapy, Ruan Xiangyan’s team from Beijing Obstetrics and Gynecology Hospital removed half of Ms. Li’s bilateral ovaries and processed them into 23 pieces of ovarian tissue as thin as cicada wings. A week later, the bone marrow transplant went smoothly.
In September 2018, Ms. Li's original disease was completely cured and she now has her own "little family". At this time, she thought of the ovarian tissue that had been frozen two years ago, so she came to Beijing Obstetrics and Gynecology Hospital to find Ruan Xiangyan.
After completing various tests, 6 pieces of Ms. Li's ovarian tissue were returned to the body. Three months later, the long-lost menstruation returned, and the menopausal symptoms slowly disappeared. On December 31 last year, she became pregnant, becoming the first patient in China to have a natural pregnancy after cryopreserved ovarian tissue transplantation.
Ruan Xiangyan processes ovarian tissue in the ovarian tissue cryopreservation bank
On August 31 this year, a new life came into this world. "The weight is 3345 grams, the height is 49 cm, the score is 10 points, and the development is very good!"
The birth of the "cryopreserved baby" is the third time that Ruan Xiangyan's team has achieved a breakthrough in the history of reproductive medicine in China, following the successful transplantation of China's first cryopreserved ovarian tissue in 2016 and the first natural pregnancy in my country in 2020.
This is a miracle of medicine and a blessing that cryopreservation brings to mankind! In the liquid nitrogen freezing tank at minus 196°C, there are opportunities for new life. At the right time, they will be "awakened" and transplanted back into their owners.
Forward
Low-temperature freezing of tissues and organs benefits human health
Ovarian tissue preservation at Shandong Yinfeng Institute of Life Sciences
At present, in my country, many medical institutions and scientific research institutes have successively carried out research and exploration on cryopreserved ovarian tissue. Shandong Yinfeng Life Sciences Research Institute is also following the trend, and has cooperated with clinical and medical institutions such as the Infertility Diagnosis and Treatment Center of Qilu Hospital of Shandong University. In cooperation with scientific research institutions, we have effectively explored the vitrification and cryopreservation of large ovarian tissues, and conducted research on the vitrification and recovery of 15 cases of human ovarian tissue. At the same time, our hospital continues to explore and establish a tissue and organ bank on the basis of stem cell preservation and recovery. Currently, it has achieved cryopreservation and recovery of skin, severed fingers/toes, valves, amniotic membrane, blood vessels, ovarian tissue, etc.
We expect that as tissue cryopreservation and transplantation technology is promoted across the country, more patients will have hope of regaining their lives in the future.
Latest developments
Over the two days, the symposium was not only a collision of ideas but also seeds sown to advance social progress in life culture. The Shandong Yinfeng Life Science Public Welfare Foundation will continue to use technology as wings and culture as roots, collaborating with all sectors of society to enhance the quality of life for the Chinese people and build a human-centered life care system.
According to recent announcements by the Jinan Municipal Bureau of Science and Technology, 11 outstanding achievements from Jinan have been included in the 2025 "Shandong Outstanding Achievements Report" project. Among them is the globally first-of-its-kind ovarian tissue dual-activation technology developed by Shandong Silver Med Life Science Research Institute (Jinan).
Recently, Frigid Zone Medicine, an authoritative international journal in the field of cryomedicine, published an important review titled "Advances in the Detection Methods for Assessing the Viability of Cryopreserved Samples". Written by the team of Yinfeng Cryomedical Research Center, the article systematically reviews and analyzes various detection techniques currently used to evaluate the viability of cryopreserved cells, tissues, and organs. It also proposes key directions from the perspectives of methodological integration and future instrument development, offering crucial theoretical support and practical guidance for the long - term cryopreservation of complex tissues and organs.
Recently, the "Novel Technology for Ultra-Low Temperature Cryopreservation, Activation, and Transplantation of Human Ovarian Tissue," developed through a collaborative effort between Shandong Yinfeng Life Science Research Institute and Beijing University of Chinese Medicine Shenzhen Hospital, has been awarded the 2025 Shandong Refrigeration and Air Conditioning Science and Technology Award. This groundbreaking technology pioneers a new pathway for female fertility preservation, marking a significant leap in China’s interdisciplinary advancements in reproductive medicine and cryobiology.
On May 19, a delegation from the Chinese Training Workshop for Government Officials of Developing Countries visited the exhibition hall of Yinfeng Biological Group's Cryomedicine Research Center. Government officials from multiple countries gained in-depth insights into Yinfeng’s innovative achievements in cryobiomedicine, cell storage, genetic technology, and other fields. They engaged in discussions with the delegation on technology transfer and international cooperation, contributing to the building of a global community with a shared future for humanity.
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