Heavyweight! Prof. Gang Zhao, the main committee member of Yinfeng Cryomedicine Specialized Committee, published another article "Advanced Cryopreservation Engineering Strategies - A Critical Step in Utilizing Stem Cell Products".
Cryopreservation is known as the technique of solidifying time, by cooling biological materials (e.g. cells, tissues and organs) to low temperatures with the addition of cryoprotectants (generally -196°C liquid nitrogen preservation), and then rewarming them to normal temperatures (37°C) in an effective manner when needed, at which time the biological samples can still be restored and maintain their activity.
In recent years, low-temperature biomedicine, a less popular subject, is attracting more and more attention, attracting more and more scientists to join it. Among them, the cryopreservation technology of cells, tissues and organs, and even the entire human body continues to make progress and is gradually used in clinical applications.
On June 30, 2023, Science Magazine published the article "Frozen in time" by Warren Cornwall, detailing the first successful transplantation of vitrified-preserved and nanoheated rat kidneys by Professor John Bischof's team at the University of Minnesota (UMN). . As the most exciting research in the field of cryopreservation of tissues and organs, this article successfully appeared on the cover of Science, Volume 380, Issue 6652.
When someone suffers from respiratory arrest or cardiac arrest due to drowning, heart disease, high blood pressure, car accident, drug poisoning, gas poisoning, foreign matter blocking the respiratory tract, etc. we should provide emergency rescue in time to prevent the patient from not getting enough Timely rescue and resuscitation can cause irreversible damage to the brain and other important organs and tissues of the human body.
The team of Professor Zhao Gang, chairman of the Yinfeng Cryomedicine Expert Committee, and his collaborators published a report [Cryopreservation method of mouse follicles based on synergistic ice suppression effect]
In recent years, the incidence of malignant diseases (such as breast cancer and hematological diseases) among young women has increased. Although aggressive chemoradiotherapy or bone marrow transplantation can cure 90% of young women, these treatments can still damage their gonads. It can even lead to premature ovarian failure. In addition, many women who delay childbearing due to work or financial reasons are also affected by infertility.
On December 16, 2022, the "world's first international low-temperature biomedical research system" was officially launched. Once the news was released, it attracted the attention of many parties, including China Daily, Jinan Daily, Qilu Evening News, Qilu One Point Client Headline Channel, Today's Toutiao, Tencent News, NetEase News, Baidu News, Sina News and other mainstream media rushed to report on it.
Recently, a new world record was born in the United States: the "oldest" pair of twin newborns "turned 30 years old" just after birth. On October 31, 2022, a couple in the United States successfully gave birth to twins named Lydia and Timothy using frozen embryos donated by others (Figure 1). They were thawed and revived from donor embryos that had been frozen for 30 years.
On August 3, 2022, the team of neurobiologist Nenad Sestan of Yale University School of Medicine in the United States published the "Sow Resurrection" experiment and its results in "Nature", which attracted widespread attention and discussion. This overturns the long-held belief that brain death is irreversible.
Recently, the Cryomedicine Center of Shandong Yinfeng Life Sciences Research Institute (the research unit of our foundation) once again obtained the invention patent for "a placental tissue matrix material and its preparation method". Up to now, the total number of patent authorizations granted by the cryogenic medicine team from the State Intellectual Property Office has reached 25.
According to a recent paper in the journal "Materials", researchers from Brigham and Women's Hospital and Harvard Medical School combined 3D bioprinting with cryopreservation technology to create tissue that can be stored in a freezer at minus 196°C. , and can be defrosted in minutes for immediate use.
Recently, CNN reported that American experts plan to "resurrection" the mammoth and plan to breed the first batch of "elephant cubs" within 4-6 years. This project, which is close to science fiction, is led by Professor George Church of Harvard Medical School. Currently, the project has received an investment of US$15 million.
A new 3D printable polymer nanocomposite ink has incredible properties and finds widespread use in aerospace, medicine and electronics. Mechanical engineering researchers at Michigan Technological University in the United States have invented a method to use carbon nanotubes (CNTs) to make 3D printing nanocomposite polymer ink, which is expected to replace traditional epoxy resin.
For natural life, aging and death are inevitable. A common hallmark of aging is that cells slowly lose their ability to produce new, healthy cells to repair damage. However, as both vertebrates, some Pacific rockfish can live for more than 200 years, while others can only live for about 10 years. The life span of the two differs by 20 times! This also makes the former one of the longest-lived vertebrates. This difference in lifespan has attracted keen interest among scientists.