World's first! "Pig liver" successfully transplanted into the human body


On March 10, led by Academician Dou Kefeng of the Chinese Academy of Sciences and Director Tao Kaishan from Hepatological Surgery Department, Xijing Hospital of Air Force Military Medical University made a major breakthrough in the clinical research of liver heterotransplantation: the whole liver of a multi-gene edited pig was successfully transplanted into a brain-dead patient using the auxiliary liver transplantation method. During the operation, the transplanted liver secreted bile immediately after blood flow was restored with no hyperacute rejection, and functioned continuously for more than 96 hours.

Heavyweight! Prof. Gang Zhao, the main committee member of Yinfeng Cryomedicine Specialized Committee, published another article "Advanced Cryopreservation Engineering Strategies - A Critical Step in Utilizing Stem Cell Products".


Cryopreservation is known as the technique of solidifying time, by cooling biological materials (e.g. cells, tissues and organs) to low temperatures with the addition of cryoprotectants (generally -196°C liquid nitrogen preservation), and then rewarming them to normal temperatures (37°C) in an effective manner when needed, at which time the biological samples can still be restored and maintain their activity.

Heavy! Professor Zhao Gang, chairman of our special committee, jointly published an important article - "Principles and Progress of Cell Cryopreservation"


In recent years, low-temperature biomedicine, a less popular subject, is attracting more and more attention, attracting more and more scientists to join it. Among them, the cryopreservation technology of cells, tissues and organs, and even the entire human body continues to make progress and is gradually used in clinical applications.

Science's latest cover article: Vital organs resuscitated after cryogenic freezing


On June 30, 2023, Science Magazine published the article "Frozen in time" by Warren Cornwall, detailing the first successful transplantation of vitrified-preserved and nanoheated rat kidneys by Professor John Bischof's team at the University of Minnesota (UMN). . As the most exciting research in the field of cryopreservation of tissues and organs, this article successfully appeared on the cover of Science, Volume 380, Issue 6652.


Twin babies who "traveled through time and space" for 30 years finally found parents willing to adopt them

Recently, a new world record was born in the United States: the "oldest" pair of twin newborns "turned 30 years old" just after birth. On October 31, 2022, a couple in the United States successfully gave birth to twins named Lydia and Timothy using frozen embryos donated by others (Figure 1). They were thawed and revived from donor embryos that had been frozen for 30 years.


Scientists "resurrected" a pig, how far are humans from resurrecting the dead?

On August 3, 2022, the team of neurobiologist Nenad Sestan of Yale University School of Medicine in the United States published the "Sow Resurrection" experiment and its results in "Nature", which attracted widespread attention and discussion. This overturns the long-held belief that brain death is irreversible.


The cryogenic medicine team of our hospital won the 25th invention patent

Recently, the Cryomedicine Center of Shandong Yinfeng Life Sciences Research Institute (the research unit of our foundation) once again obtained the invention patent for "a placental tissue matrix material and its preparation method". Up to now, the total number of patent authorizations granted by the cryogenic medicine team from the State Intellectual Property Office has reached 25.


-196℃+3D printing, new technology makes biological tissue storage more convenient

According to a recent paper in the journal "Materials", researchers from Brigham and Women's Hospital and Harvard Medical School combined 3D bioprinting with cryopreservation technology to create tissue that can be stored in a freezer at minus 196°C. , and can be defrosted in minutes for immediate use.


Crazy: Scientists decide to use DNA to "resurrect" mammoths within 6 years

Recently, CNN reported that American experts plan to "resurrection" the mammoth and plan to breed the first batch of "elephant cubs" within 4-6 years. This project, which is close to science fiction, is led by Professor George Church of Harvard Medical School. Currently, the project has received an investment of US$15 million.


breakthrough! 3D nano-ink breaks the bottleneck

A new 3D printable polymer nanocomposite ink has incredible properties and finds widespread use in aerospace, medicine and electronics. Mechanical engineering researchers at Michigan Technological University in the United States have invented a method to use carbon nanotubes (CNTs) to make 3D printing nanocomposite polymer ink, which is expected to replace traditional epoxy resin.


"Science" big news! The secret of longevity that can live for 200 years was found deep in the ocean!

For natural life, aging and death are inevitable. A common hallmark of aging is that cells slowly lose their ability to produce new, healthy cells to repair damage. However, as both vertebrates, some Pacific rockfish can live for more than 200 years, while others can only live for about 10 years. The life span of the two differs by 20 times! This also makes the former one of the longest-lived vertebrates. This difference in lifespan has attracted keen interest among scientists.


Freezing juvenile testicular tissue to preserve male fertility

Nowadays, the incidence rate of cancer is getting higher and higher, and it is getting younger and younger. Many people are not yet married and have children, but unfortunately they are suffering from the disease. Because once you suffer from cancer, the use of radiotherapy, chemotherapy and other methods are likely to damage the reproductive organs, affect the production of male or female hormones, and cause the patient to be infertile.


Smaller than the diameter of a hair! New breakthroughs in the field of micro- and nano-robots

Not long ago, an international team including Chinese scientists developed a "miniature paper crane" that is smaller than the diameter of a hair. Under the influence of voltage, it can automatically fold from a flat surface in less than one second. As a new micro-actuator with a size of only tens of microns, this imaginative paper crane is another breakthrough in the field of micro-nano robot research and development.


Japanese Wagyu beef grown in laboratory using 3D bioprinting technology

According to the Global Times, Japanese scientists recently used 3D printing technology to successfully create Wagyu beef with a marbled effect. The manufactured meat products contain protein, fat, and even blood vessels. Researchers say such "cultured" steaks are more environmentally friendly than their traditional counterparts. Wagyu is an expensive and highly sought-after beef breed from Japan.