Heavyweight! Prof. Gang Zhao, the main committee member of Yinfeng Cryomedicine Specialized Committee, published another article "Advanced Cryopreservation Engineering Strategies - A Critical Step in Utilizing Stem Cell Products".
Cryopreservation is known as the technique of solidifying time, by cooling biological materials (e.g. cells, tissues and organs) to low temperatures with the addition of cryoprotectants (generally -196°C liquid nitrogen preservation), and then rewarming them to normal temperatures (37°C) in an effective manner when needed, at which time the biological samples can still be restored and maintain their activity.
In recent years, low-temperature biomedicine, a less popular subject, is attracting more and more attention, attracting more and more scientists to join it. Among them, the cryopreservation technology of cells, tissues and organs, and even the entire human body continues to make progress and is gradually used in clinical applications.
On June 30, 2023, Science Magazine published the article "Frozen in time" by Warren Cornwall, detailing the first successful transplantation of vitrified-preserved and nanoheated rat kidneys by Professor John Bischof's team at the University of Minnesota (UMN). . As the most exciting research in the field of cryopreservation of tissues and organs, this article successfully appeared on the cover of Science, Volume 380, Issue 6652.
Nowadays, the incidence rate of cancer is getting higher and higher, and it is getting younger and younger. Many people are not yet married and have children, but unfortunately they are suffering from the disease. Because once you suffer from cancer, the use of radiotherapy, chemotherapy and other methods are likely to damage the reproductive organs, affect the production of male or female hormones, and cause the patient to be infertile.
According to the Global Times, Japanese scientists recently used 3D printing technology to successfully create Wagyu beef with a marbled effect. The manufactured meat products contain protein, fat, and even blood vessels. Researchers say such "cultured" steaks are more environmentally friendly than their traditional counterparts. Wagyu is an expensive and highly sought-after beef breed from Japan.
Not long ago, an international team including Chinese scientists developed a "miniature paper crane" that is smaller than the diameter of a hair. Under the influence of voltage, it can automatically fold from a flat surface in less than one second. As a new micro-actuator with a size of only tens of microns, this imaginative paper crane is another breakthrough in the field of micro-nano robot research and development.
Recently, Beijing Obstetrics and Gynecology Hospital welcomed a special baby. This is the first child in China to become pregnant naturally after a successful transplant of cryopreserved ovarian tissue. The 45-day re-examination results showed that all indicators of the baby were normal and everything was healthy!
Recently, NYU Langone Medical Center conducted a special experiment - transplanting kidneys from pigs into humans for the first time, and there has been no rejection reaction so far. The kidney for this experiment came from a gene-edited pig.
On October 20, 2021, the Cryogenic Medicine Research Center of Shandong Yinfeng Life Sciences Research Institute (the research unit of our foundation) welcomed the Yinfeng second-generation upgraded high-precision, long-span, and large-scale programmed cooling instrument. The overall appearance of this equipment , the operation interface, the spatial layout of the temperature monitoring sensor, and the traveling mode of the liquid nitrogen steam vortex have all been optimized and upgraded.
Research in basic science is supported by experimental data one by one, and the same is true for exploration in life sciences. The generation of every experimental data is inseparable from the contribution and dedication of experimental animals, and they are all precious.
Large-segment bone defects are common clinical diseases, and stem cells and bone tissue engineering are considered to be a promising method for bone regeneration. Recently, a team from Shandong Yinfeng Life Sciences Research Institute and Shandong University collaborated to study a nanocellulose membrane platform for multi-lineage differentiation of stem cells to biomimetically construct bioactive three-dimensional bone-like tissue, which can significantly promote the rapid growth of new bone and capillary growth. Rapid formation of blood vessels and nerve fibers.
A few days ago, the Department of Science and Technology of Shandong Province issued the "Announcement on the Preparation of the First Batch of Provincial New R&D Institutions in 2020". Approved to be selected into the first batch of “Provincial New R&D Institutions” in Shandong Province.
At present, cryopreservation technology (temperature at minus 196°C) has become the most commonly used and effective long-term preservation method for single cells, and has successfully achieved human sperm, oocytes, embryos, red blood cells, monocytes, embryonic stem cells, and hematopoiesis. Vitrified preservation of stem cells, pancreatic islets, etc. At the same time, cryopreservation is relatively more difficult because tissues and organs contain multiple types of cells, as well as large volumes and complex spatial structures.