World's first! "Pig liver" successfully transplanted into the human body


On March 10, led by Academician Dou Kefeng of the Chinese Academy of Sciences and Director Tao Kaishan from Hepatological Surgery Department, Xijing Hospital of Air Force Military Medical University made a major breakthrough in the clinical research of liver heterotransplantation: the whole liver of a multi-gene edited pig was successfully transplanted into a brain-dead patient using the auxiliary liver transplantation method. During the operation, the transplanted liver secreted bile immediately after blood flow was restored with no hyperacute rejection, and functioned continuously for more than 96 hours.

Heavyweight! Prof. Gang Zhao, the main committee member of Yinfeng Cryomedicine Specialized Committee, published another article "Advanced Cryopreservation Engineering Strategies - A Critical Step in Utilizing Stem Cell Products".


Cryopreservation is known as the technique of solidifying time, by cooling biological materials (e.g. cells, tissues and organs) to low temperatures with the addition of cryoprotectants (generally -196°C liquid nitrogen preservation), and then rewarming them to normal temperatures (37°C) in an effective manner when needed, at which time the biological samples can still be restored and maintain their activity.

Heavy! Professor Zhao Gang, chairman of our special committee, jointly published an important article - "Principles and Progress of Cell Cryopreservation"


In recent years, low-temperature biomedicine, a less popular subject, is attracting more and more attention, attracting more and more scientists to join it. Among them, the cryopreservation technology of cells, tissues and organs, and even the entire human body continues to make progress and is gradually used in clinical applications.

Science's latest cover article: Vital organs resuscitated after cryogenic freezing


On June 30, 2023, Science Magazine published the article "Frozen in time" by Warren Cornwall, detailing the first successful transplantation of vitrified-preserved and nanoheated rat kidneys by Professor John Bischof's team at the University of Minnesota (UMN). . As the most exciting research in the field of cryopreservation of tissues and organs, this article successfully appeared on the cover of Science, Volume 380, Issue 6652.


Hard-won! my country’s first “frozen baby” undergoes health review

Recently, Beijing Obstetrics and Gynecology Hospital welcomed a special baby. This is the first child in China to become pregnant naturally after a successful transplant of cryopreserved ovarian tissue. The 45-day re-examination results showed that all indicators of the baby were normal and everything was healthy!


A world first! Pig kidney transplanted into human body, functions normally, no rejection yet

Recently, NYU Langone Medical Center conducted a special experiment - transplanting kidneys from pigs into humans for the first time, and there has been no rejection reaction so far. The kidney for this experiment came from a gene-edited pig.


Another big guy joins! The ultimate pursuit of many entrepreneurs is this

On October 20, 2021, the Cryogenic Medicine Research Center of Shandong Yinfeng Life Sciences Research Institute (the research unit of our foundation) welcomed the Yinfeng second-generation upgraded high-precision, long-span, and large-scale programmed cooling instrument. The overall appearance of this equipment , the operation interface, the spatial layout of the temperature monitoring sensor, and the traveling mode of the liquid nitrogen steam vortex have all been optimized and upgraded.


Pay tribute to the heroes behind the scenes - using experimental data to support the exploration of life sciences

Research in basic science is supported by experimental data one by one, and the same is true for exploration in life sciences. The generation of every experimental data is inseparable from the contribution and dedication of experimental animals, and they are all precious.


Yinfeng Institute of Biological Sciences’ research results on “Stem Cells Promote New Bone Growth” were published in foreign journals

Large-segment bone defects are common clinical diseases, and stem cells and bone tissue engineering are considered to be a promising method for bone regeneration. Recently, a team from Shandong Yinfeng Life Sciences Research Institute and Shandong University collaborated to study a nanocellulose membrane platform for multi-lineage differentiation of stem cells to biomimetically construct bioactive three-dimensional bone-like tissue, which can significantly promote the rapid growth of new bone and capillary growth. Rapid formation of blood vessels and nerve fibers.


Yinfeng Institute of Biological Sciences was selected into the first batch of "Provincial New R&D Institutions", accumulating new momentum for industry-university-research collaboration

A few days ago, the Department of Science and Technology of Shandong Province issued the "Announcement on the Preparation of the First Batch of Provincial New R&D Institutions in 2020". Approved to be selected into the first batch of “Provincial New R&D Institutions” in Shandong Province.


Tissue and organ transplantation

The emergence and development of human tissue and organ transplantation technology is a huge progress in the development of modern biomedicine in the 20th century, saving countless lives and health, and bringing hope to countless patients and their families.


Cryopreservation of tissues and organs

At present, cryopreservation technology (temperature at minus 196°C) has become the most commonly used and effective long-term preservation method for single cells, and has successfully achieved human sperm, oocytes, embryos, red blood cells, monocytes, embryonic stem cells, and hematopoiesis. Vitrified preservation of stem cells, pancreatic islets, etc. At the same time, cryopreservation is relatively more difficult because tissues and organs contain multiple types of cells, as well as large volumes and complex spatial structures.


Tissues and Organs

The human body is composed of about 40 trillion to 60 trillion cells. It is composed of cell groups and intercellular substance with the same or similar shape and function. It is a structural unit composed of a variety of tissues that can perform a (specific) function. That is the organ. The four major tissues of the human body are: epithelial tissue, connective tissue, muscle tissue, and nervous tissue; the structural characteristics of different organs are adapted to their functions, such as: eyes, ears, nose, tongue and other sensory organs, and another example: internal organs Organs heart, liver, lungs, stomach, kidneys, etc.


Shandong Yinfeng Life Sciences Research Institute completed the transfer of off-site volunteers and cryopreservation of human bodies for the first time

At 14:30 pm on June 19, 2018, at Shandong Yinfeng Institute of Life Sciences (hereinafter referred to as "Yinfeng Institute of Life Sciences"), a special farewell visit was a quick glance through the glass window, and then another Watching a kind old man being transferred to a liquid nitrogen tank at -196°C. Those who came to visit her were her close relatives - her husband, who had been with her for 53 years, her four children whom she had worked hard to raise, and her little granddaughter, whom she regarded as a treasure, and more than a dozen people.